Cohort Summary

This dashboard provides an overview of the data available within the Generation Scotland cohort. Use the navigation tabs above to explore participant characteristics, linked health records, and available biological and clinical data. Generation Scotland is a large, family-based research study designed to investigate the genetic and environmental determinants of health and disease. Participants contribute questionnaire data and biological samples, which are linked to NHS health records and enhanced through laboratory-based analyses. Together, these data form a rich resource for population health research.

Originally established as the Scottish Family Health Study (SFHS) , Generation Scotland recruited participants between 2006 and 2011 through GP practices across Glasgow, Tayside, Ayrshire, Arran, and Northeast Scotland. During this phase, participants completed baseline questionnaires and attended clinic visits for blood sample collection.

The most recent recruitment phase, NextGenScot (2022–2025) , expanded the cohort through an online data-collection platform and remote saliva sampling. This phase added over 16,000 participants , with more than 10,000 saliva samples collected for genomic analysis, alongside extensive new phenotype data. Existing Generation Scotland participants were also invited to take part, resulting in partial overlap between cohorts.

Further Information

Interested in gaining access to our research data? View more details about our data and access policies

Ready to apply? Submit an access request via the Access Portal

For enquiries about Generation Scotland, please contact us at gen.scot@ed.ac.uk

Total Volunteers 41,211
Total Families 6,862
NHS Linkage 37,634 (91%)
Genotype Data 20,019 (49%)
Methylation 18,858 (46%)
Proteomics 18,826 (46%)

NGS omics analysis is currently ongoing

Demographics

Demographic summaries include original GS participants only. NextGen participants will be added in due course and are briefly summarised in the Next Generation Scotland tab.
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Age and sex was self-reported in the baseline questionnaire.

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Derived from postcode.

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Derived from postcode.

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Educational attainment was self-reported in the baseline questionnaire.

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Smoking status was self-reported in the baseline questionnaire.

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Ethnicity was self-reported in the baseline questionnaire.

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Derived from postcode.

Disease Cases by ICD10 Code

Review the cases of ICD10 disease codes in General/Acute and Inpatient Day Case dataset (SMR01) for Generation Scotland participants. Bars can be subset to show the proportion of cases by sex, age, omics availability and incident cases (if the diagnosis was made after an individual's sample was collected at recruitment). Summaries only include the first occurance of an ICD code per individual.

NextGenScot data will be added in due course.

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Diseases with <10 cases will not be displayed. Breakdowns with <10 individuals in any category will not be displayed.

ICD10 Code List

Disease Cases by CALIBER Phenotype

Review the cases of CALIBER diseases in primary and secondary care within the GS dataset. Bars can be subset to show the proportion of cases by sex, age, omics availability and incident cases (if the diagnosis was made after an individual's sample was collected at recruitment). Summaries only include the first occurance of a CALIBER phenotype diagnosis per individual.

NextGenScot data will be added in due course.

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Diseases with <10 cases will not be displayed. Breakdowns with <10 individuals in any category will not be displayed.

CALIBER Phenotype List

Prescriptions

Review the prescriptions from the Prescribing Information Service (PIS) dataset. Bars can be subset to show the proportion of cases by sex, age, omics availability and incident cases (if the diagnosis was made after an individual's sample was collected at recruitment). Summaries only include the first occurance of a prescription test per individual.

NextGenScot data will be added in due course.

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Prescriptions with <10 cases will not be displayed. Breakdowns with <10 individuals in any category will not be displayed.

BNF Drug List

SCI-Store Lab Tests

Review the lab test results within the GS dataset. Bars can be subset to show the proportion of results by sex, age, omics availability and incident results (if the diagnosis was made after an individual's sample was collected at recruitment). Summaries only include the first occurance of a lab test per individual.

NextGenScot data will be added in due course.

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Lab tests with <10 cases will not be displayed. Breakdowns with <10 individuals in any category will not be displayed.

Lab Test List

Participant Filter Tool

Total Participants

Omics Data

NextGenScot omics data will be added in due course.

GS Recruitment Phase

Demographics

Re-Contact


Re-Contact Study Participation

Other

Linked Data Summary

Dataset Overview